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Projection · SURMOUNT-1

Zepbound weight loss from 300 lb

If you match the trial average at 15 mg, you'd be about 237 lb by week 72.

Clinician review pending Updated
Avg loss by week 72
−63lb
15 mg, 20.9%
Weight at week 72
237lb
if you match the average
Placebo group
−9lb
3.1%, same trial
Trial length
72weeks
SURMOUNT-1
Show the math
Loss = 300 lb × 20.9% = 63 lb
Projected weight from 300 lb
2322502692873050122436486072weeks

Zepbound 15 mgZepbound 10 mgZepbound 5 mgPlacebo

Week by week

WeekZepbound 15 mgZepbound 10 mgZepbound 5 mg
Week 4−10 lb · 290−9 lb · 291−7 lb · 293
Week 8−19 lb · 281−17 lb · 283−13 lb · 287
Week 12−26 lb · 274−24 lb · 276−19 lb · 281
Week 16−32 lb · 268−30 lb · 270−23 lb · 277
Week 24−42 lb · 258−39 lb · 261−30 lb · 270
Week 36−51 lb · 249−48 lb · 252−37 lb · 263
Week 52−58 lb · 242−55 lb · 245−42 lb · 258
Week 72−63 lb · 237−58 lb · 242−45 lb · 255

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 300 lb

LossPoundsNew weight
5%15 lb285 lb
10%30 lb270 lb
15%45 lb255 lb
20%60 lb240 lb
25%75 lb225 lb

At 15 mg, about 9 in 10 people lost at least 5% of body weight and more than half lost at least 20%.

How this projection works

We take the average loss reported in SURMOUNT-1 (2,539 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 72. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Zepbound at 280 lbZepbound at 290 lbZepbound at 310 lbZepbound at 320 lbWegovy at 300 lbWegovy pill at 300 lbSaxenda at 300 lb

Common questions

How much weight can you lose on Zepbound at 300 lb?

If you matched the SURMOUNT-1 average at 15 mg (20.9%), you'd lose about 63 lb over 72 weeks. Many people lose more or less.

How fast does Zepbound weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 42 lb at 15 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Zepbound prescribing information (FDA label on DailyMed)
  2. SURMOUNT-1 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error