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oral semaglutide · Novo Nordisk

Wegovy pill at a glance

Daily semaglutide tablet for weight management, the first GLP-1 pill for obesity. Facts from the FDA label, laid out the same way for every medicine.

Clinician review pending Updated
Avg weight loss
13.6%
25 mg, 64 wk (OASIS 4)
Starting dose
1.5 mg
once daily
Highest dose
25 mg
on the label
Missed dose
skip and resume the next day
label rule

What it's approved for

  • Chronic weight management, with diet and exercise, in adults with obesity or overweight with at least one weight-related condition
  • Check the current label for any added uses since approval

How it works

It mimics GLP-1, a gut hormone released after meals. It slows stomach emptying, lowers appetite and helps the pancreas release insulin when blood sugar is high.

Wegovy pill has a half-life of about 1 week for the injection, so steady levels take 4 to 5 weeks.

The same medicine is sold as Rybelsus. See Wegovy pill vs Rybelsus.

Dose steps on the label

Increase every 30 days per the label schedule. Maintenance: 25 mg once daily.

1.5 mg30 days4 mg30 days9 mg30 days25 mgongoing

What the main trial found

Wegovy pill 25 mgOASIS 4 · 64 wk
13.6%
Placebosame trial
2.2%
307 adults with obesity or overweight, without diabetes. Weight loss was similar to injectable Wegovy when tablets were taken as directed.
Boxed warningRisk of thyroid C-cell tumors. In rodent studies these medicines caused thyroid C-cell tumors. It isn't known whether they cause them in people, including medullary thyroid carcinoma (MTC). Don't use them if you or a family member has had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Cost snapshot

OptionPer monthPer yearNote
1.5 mg and 4 mg tablets (self-pay)$149$1,788Self-pay
9 mg and 25 mg tablets (self-pay)$299$3,588Self-pay

Compiled mid-2026 from manufacturer announcements; re-checked monthly. All savings options.

Everything about Wegovy pill

Dosage

Every dose step, timing and the maximum

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Side effects

How common each one is vs placebo

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Cost and savings

List price, self-pay and savings cards

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Insurance coverage

Prior authorization and appeals

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Missed dose

What the label says to do

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Storage

Fridge, room temperature and travel

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How to take it

Step by step, from the label

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Warnings

Boxed warning and who shouldn't use it

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Explainer · 0:23

1 · THE GUT HORMONE GLP-1 the medicine copies it and lasts for days 2 · SLOWER EMPTYING full sooner, full for longer 3 · THE BRAIN lowhigh HUNGER 4 · BLOOD SUGAR blood sugar after a meal + insulin withoutwith GLP-1 tirzepatide: + GIP 0:23 · voiced · captions on
After you eat, your gut releases a hormone called GLP-1. GLP-1 medicines copy it, but last much longer in the body.
0:00 / 0:23
How GLP-1 medicines work
Read the transcript
  1. After you eat, your gut releases a hormone called GLP-1. GLP-1 medicines copy it, but last much longer in the body.
  2. It slows how fast your stomach empties, so you feel full sooner and stay full for longer.
  3. It also acts on appetite centers in the brain, which quiets hunger and constant thoughts about food.
  4. When blood sugar is high, it helps the pancreas release insulin. Tirzepatide also acts on a second gut hormone, GIP.

Compare Wegovy pill

Zepbound vs Wegovy pillWegovy vs Wegovy pillOzempic vs Wegovy pillMounjaro vs Wegovy pillWegovy pill vs RybelsusWegovy pill vs SaxendaWegovy pill vs TrulicityWegovy pill vs Victoza

Common questions

What is Wegovy pill?

Wegovy pill is oral semaglutide, a GLP-1 receptor agonist (tablet) made by Novo Nordisk. It's a once daily tablet.

What is the starting dose of Wegovy pill?

The label starts at 1.5 mg, 30 days first. Increase every 30 days per the label schedule.

What is the highest dose of Wegovy pill?

The highest dose on the label is 25 mg once daily.

How much weight do people lose on Wegovy pill?

In OASIS 4, people on 25 mg lost an average of 13.6% of body weight over 64 weeks, vs 2.2% on placebo. Results vary widely.

What if I miss a dose of Wegovy pill?

If you miss a dose, skip it and take the next dose the following day. Don't take two tablets to make up for it.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error

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