Step by step
- Step 1Inject under the skin of your stomach (at least 2 inches from the belly button), front of the thigh, or back of the upper arm (best done by someone else).
- Step 2Rotate the injection site every week.
- Step 3Use it any time of day, with or without meals, on the same day each week.
- Step 4Single-dose vials need a separate syringe and needle; ask your pharmacist to show you the technique.
Timing
You can change your weekly injection day as long as the last dose was at least 3 days (72 hours) earlier.
Take the missed dose as soon as possible within 4 days (96 hours). If more than 4 days have passed, skip it and take the next dose on your usual day.
Eating while you take it
Smaller meals, stopping when you're full and going easy on greasy foods can help with nausea. Make protein the first part of each meal: find your protein floor.
How to use it
- Enter your numbers. Switch between US and metric units at any time.
- Results update as you type, and the formula is shown so you can check it.
- Copy the link, save the plan on this device, or print it for your next appointment.

These are estimates, not a diagnosis. A clinician can account for your health history and medicines.
Common questions
When is the best time to take Zepbound?
You can change your weekly injection day as long as the last dose was at least 3 days (72 hours) earlier.
Does Zepbound have to be taken with food?
No. The injection can be used with or without meals, at any time of day.
Sources
Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error