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Projection · SURMOUNT-1

Zepbound weight loss from 320 lb

If you match the trial average at 15 mg, you'd be about 253 lb by week 72.

Clinician review pending Updated
Avg loss by week 72
−67lb
15 mg, 20.9%
Weight at week 72
253lb
if you match the average
Placebo group
−10lb
3.1%, same trial
Trial length
72weeks
SURMOUNT-1
Show the math
Loss = 320 lb × 20.9% = 67 lb
Projected weight from 320 lb
2482672873063250122436486072weeks

Zepbound 15 mgZepbound 10 mgZepbound 5 mgPlacebo

Week by week

WeekZepbound 15 mgZepbound 10 mgZepbound 5 mg
Week 4−11 lb · 309−10 lb · 310−8 lb · 312
Week 8−20 lb · 300−19 lb · 301−14 lb · 306
Week 12−28 lb · 292−26 lb · 294−20 lb · 300
Week 16−34 lb · 286−32 lb · 288−25 lb · 295
Week 24−44 lb · 276−42 lb · 278−32 lb · 288
Week 36−55 lb · 265−51 lb · 269−39 lb · 281
Week 52−62 lb · 258−58 lb · 262−45 lb · 275
Week 72−67 lb · 253−62 lb · 258−48 lb · 272

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 320 lb

LossPoundsNew weight
5%16 lb304 lb
10%32 lb288 lb
15%48 lb272 lb
20%64 lb256 lb
25%80 lb240 lb

At 15 mg, about 9 in 10 people lost at least 5% of body weight and more than half lost at least 20%.

How this projection works

We take the average loss reported in SURMOUNT-1 (2,539 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 72. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Zepbound at 300 lbZepbound at 310 lbZepbound at 330 lbZepbound at 340 lbWegovy at 320 lbWegovy pill at 320 lbSaxenda at 320 lb

Common questions

How much weight can you lose on Zepbound at 320 lb?

If you matched the SURMOUNT-1 average at 15 mg (20.9%), you'd lose about 67 lb over 72 weeks. Many people lose more or less.

How fast does Zepbound weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 44 lb at 15 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Zepbound prescribing information (FDA label on DailyMed)
  2. SURMOUNT-1 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error