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Projection · STEP 1

Wegovy weight loss from 300 lb

If you match the trial average at 2.4 mg, you'd be about 255 lb by week 68.

Clinician review pending Updated
Avg loss by week 68
−45lb
2.4 mg, 14.9%
Weight at week 68
255lb
if you match the average
Placebo group
−7lb
2.4%, same trial
Trial length
68weeks
STEP 1
Show the math
Loss = 300 lb × 14.9% = 45 lb
Projected weight from 300 lb
2522652782913040112334455768weeks

Wegovy 2.4 mgPlacebo

Week by week

WeekWegovy 2.4 mg
Week 4−8 lb · 292
Week 8−14 lb · 286
Week 12−19 lb · 281
Week 16−24 lb · 276
Week 24−31 lb · 269
Week 36−37 lb · 263
Week 52−42 lb · 258
Week 68−45 lb · 255

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 300 lb

LossPoundsNew weight
5%15 lb285 lb
10%30 lb270 lb
15%45 lb255 lb
20%60 lb240 lb
25%75 lb225 lb

86% lost at least 5%, 69% lost at least 10%, about half lost at least 15% and about a third lost at least 20%.

How this projection works

We take the average loss reported in STEP 1 (1,961 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 68. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy at 300 lb?

If you matched the STEP 1 average at 2.4 mg (14.9%), you'd lose about 45 lb over 68 weeks. Many people lose more or less.

How fast does Wegovy weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 31 lb at 2.4 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy prescribing information (FDA label on DailyMed)
  2. STEP 1 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error