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Projection · OASIS 4

Wegovy pill weight loss from 300 lb

If you match the trial average at 25 mg, you'd be about 259 lb by week 64.

Clinician review pending Updated
Avg loss by week 64
−41lb
25 mg, 13.6%
Weight at week 64
259lb
if you match the average
Placebo group
−7lb
2.2%, same trial
Trial length
64weeks
OASIS 4
Show the math
Loss = 300 lb × 13.6% = 41 lb
Projected weight from 300 lb
2562682802913030112132435364weeks

Wegovy pill 25 mgPlacebo

Week by week

WeekWegovy pill 25 mg
Week 4−7 lb · 293
Week 8−13 lb · 287
Week 12−18 lb · 282
Week 16−23 lb · 277
Week 24−29 lb · 271
Week 36−35 lb · 265
Week 52−39 lb · 261
Week 64−41 lb · 259

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 300 lb

LossPoundsNew weight
5%15 lb285 lb
10%30 lb270 lb
15%45 lb255 lb
20%60 lb240 lb
25%75 lb225 lb

Weight loss was similar to injectable Wegovy when tablets were taken as directed.

How this projection works

We take the average loss reported in OASIS 4 (307 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 64. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy pill at 300 lb?

If you matched the OASIS 4 average at 25 mg (13.6%), you'd lose about 41 lb over 64 weeks. Many people lose more or less.

How fast does Wegovy pill weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 29 lb at 25 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error