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Projection · SURMOUNT-1

Zepbound weight loss from 280 lb

If you match the trial average at 15 mg, you'd be about 221 lb by week 72.

Clinician review pending Updated
Avg loss by week 72
−59lb
15 mg, 20.9%
Weight at week 72
221lb
if you match the average
Placebo group
−9lb
3.1%, same trial
Trial length
72weeks
SURMOUNT-1
Show the math
Loss = 280 lb × 20.9% = 59 lb
Projected weight from 280 lb
2172342512682850122436486072weeks

Zepbound 15 mgZepbound 10 mgZepbound 5 mgPlacebo

Week by week

WeekZepbound 15 mgZepbound 10 mgZepbound 5 mg
Week 4−9 lb · 271−9 lb · 271−7 lb · 273
Week 8−17 lb · 263−16 lb · 264−13 lb · 267
Week 12−24 lb · 256−23 lb · 257−17 lb · 263
Week 16−30 lb · 250−28 lb · 252−22 lb · 258
Week 24−39 lb · 241−36 lb · 244−28 lb · 252
Week 36−48 lb · 232−45 lb · 235−34 lb · 246
Week 52−55 lb · 225−51 lb · 229−39 lb · 241
Week 72−59 lb · 221−55 lb · 225−42 lb · 238

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 280 lb

LossPoundsNew weight
5%14 lb266 lb
10%28 lb252 lb
15%42 lb238 lb
20%56 lb224 lb
25%70 lb210 lb

At 15 mg, about 9 in 10 people lost at least 5% of body weight and more than half lost at least 20%.

How this projection works

We take the average loss reported in SURMOUNT-1 (2,539 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 72. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Zepbound at 260 lbZepbound at 270 lbZepbound at 290 lbZepbound at 300 lbWegovy at 280 lbWegovy pill at 280 lbSaxenda at 280 lb

Common questions

How much weight can you lose on Zepbound at 280 lb?

If you matched the SURMOUNT-1 average at 15 mg (20.9%), you'd lose about 59 lb over 72 weeks. Many people lose more or less.

How fast does Zepbound weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 39 lb at 15 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Zepbound prescribing information (FDA label on DailyMed)
  2. SURMOUNT-1 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error