Projected loss by start weight

Start weight	Lost by week 72	End weight	Lost by week 24
150 lb	−31 lb	119 lb	−21 lb
160 lb	−33 lb	127 lb	−22 lb
170 lb	−36 lb	134 lb	−24 lb
180 lb	−38 lb	142 lb	−25 lb
190 lb	−40 lb	150 lb	−26 lb
200 lb	−42 lb	158 lb	−28 lb
210 lb	−44 lb	166 lb	−29 lb
220 lb	−46 lb	174 lb	−31 lb
230 lb	−48 lb	182 lb	−32 lb
240 lb	−50 lb	190 lb	−33 lb
250 lb	−52 lb	198 lb	−35 lb
260 lb	−54 lb	206 lb	−36 lb
270 lb	−56 lb	214 lb	−38 lb
280 lb	−59 lb	221 lb	−39 lb
290 lb	−61 lb	229 lb	−40 lb
300 lb	−63 lb	237 lb	−42 lb
310 lb	−65 lb	245 lb	−43 lb
320 lb	−67 lb	253 lb	−44 lb
330 lb	−69 lb	261 lb	−46 lb
340 lb	−71 lb	269 lb	−47 lb
350 lb	−73 lb	277 lb	−49 lb
360 lb	−75 lb	285 lb	−50 lb
370 lb	−77 lb	293 lb	−51 lb
380 lb	−79 lb	301 lb	−53 lb
390 lb	−82 lb	308 lb	−54 lb
400 lb	−84 lb	316 lb	−56 lb

Based on the SURMOUNT-1 average at 15 mg (20.9% over 72 weeks). Individual results vary widely.

Explainer · 0:23

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After you eat, your gut releases a hormone called GLP-1. GLP-1 medicines copy it, but last much longer in the body.

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How GLP-1 medicines work

Read the transcript

After you eat, your gut releases a hormone called GLP-1. GLP-1 medicines copy it, but last much longer in the body.
It slows how fast your stomach empties, so you feel full sooner and stay full for longer.
It also acts on appetite centers in the brain, which quiets hunger and constant thoughts about food.
When blood sugar is high, it helps the pancreas release insulin. Tirzepatide also acts on a second gut hormone, GIP.

Sources

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error

Zepbound weight loss by start weight

Projected loss by start weight

How to use it

Sources