Zepbound 15 mgZepbound 10 mgZepbound 5 mgPlacebo
Week by week
| Week | Zepbound 15 mg | Zepbound 10 mg | Zepbound 5 mg |
|---|---|---|---|
| Week 4 | −9 lb · 261 | −9 lb · 261 | −7 lb · 263 |
| Week 8 | −17 lb · 253 | −16 lb · 254 | −12 lb · 258 |
| Week 12 | −23 lb · 247 | −22 lb · 248 | −17 lb · 253 |
| Week 16 | −29 lb · 241 | −27 lb · 243 | −21 lb · 249 |
| Week 24 | −38 lb · 232 | −35 lb · 235 | −27 lb · 243 |
| Week 36 | −46 lb · 224 | −43 lb · 227 | −33 lb · 237 |
| Week 52 | −53 lb · 217 | −49 lb · 221 | −38 lb · 232 |
| Week 72 | −56 lb · 214 | −53 lb · 217 | −40 lb · 230 |
Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.
What each milestone means at 270 lb
| Loss | Pounds | New weight |
|---|---|---|
| 5% | 14 lb | 256 lb |
| 10% | 27 lb | 243 lb |
| 15% | 40 lb | 230 lb |
| 20% | 54 lb | 216 lb |
| 25% | 68 lb | 202 lb |
At 15 mg, about 9 in 10 people lost at least 5% of body weight and more than half lost at least 20%.
How this projection works
We take the average loss reported in SURMOUNT-1 (2,539 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 72. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.
How to use it
- Enter your numbers. Switch between US and metric units at any time.
- Results update as you type, and the formula is shown so you can check it.
- Copy the link, save the plan on this device, or print it for your next appointment.
These are estimates, not a diagnosis. A clinician can account for your health history and medicines.
Other start weights
Common questions
How much weight can you lose on Zepbound at 270 lb?
If you matched the SURMOUNT-1 average at 15 mg (20.9%), you'd lose about 56 lb over 72 weeks. Many people lose more or less.
How fast does Zepbound weight loss happen?
Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 38 lb at 15 mg.
Is this a guarantee?
No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.
Sources
Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error