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Projection · OASIS 4

Wegovy pill weight loss from 270 lb

If you match the trial average at 25 mg, you'd be about 233 lb by week 64.

Clinician review pending Updated
Avg loss by week 64
−37lb
25 mg, 13.6%
Weight at week 64
233lb
if you match the average
Placebo group
−6lb
2.2%, same trial
Trial length
64weeks
OASIS 4
Show the math
Loss = 270 lb × 13.6% = 37 lb
Projected weight from 270 lb
2302412522622730112132435364weeks

Wegovy pill 25 mgPlacebo

Week by week

WeekWegovy pill 25 mg
Week 4−7 lb · 263
Week 8−12 lb · 258
Week 12−17 lb · 253
Week 16−20 lb · 250
Week 24−26 lb · 244
Week 36−31 lb · 239
Week 52−35 lb · 235
Week 64−37 lb · 233

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 270 lb

LossPoundsNew weight
5%14 lb256 lb
10%27 lb243 lb
15%40 lb230 lb
20%54 lb216 lb
25%68 lb202 lb

Weight loss was similar to injectable Wegovy when tablets were taken as directed.

How this projection works

We take the average loss reported in OASIS 4 (307 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 64. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy pill at 270 lb?

If you matched the OASIS 4 average at 25 mg (13.6%), you'd lose about 37 lb over 64 weeks. Many people lose more or less.

How fast does Wegovy pill weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 26 lb at 25 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error