Skip to content

Projection · OASIS 4

Wegovy pill weight loss from 290 lb

If you match the trial average at 25 mg, you'd be about 251 lb by week 64.

Clinician review pending Updated
Avg loss by week 64
−39lb
25 mg, 13.6%
Weight at week 64
251lb
if you match the average
Placebo group
−6lb
2.2%, same trial
Trial length
64weeks
OASIS 4
Show the math
Loss = 290 lb × 13.6% = 39 lb
Projected weight from 290 lb
2472592702822930112132435364weeks

Wegovy pill 25 mgPlacebo

Week by week

WeekWegovy pill 25 mg
Week 4−7 lb · 283
Week 8−13 lb · 277
Week 12−18 lb · 272
Week 16−22 lb · 268
Week 24−28 lb · 262
Week 36−34 lb · 256
Week 52−38 lb · 252
Week 64−39 lb · 251

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 290 lb

LossPoundsNew weight
5%14 lb276 lb
10%29 lb261 lb
15%44 lb246 lb
20%58 lb232 lb
25%72 lb218 lb

Weight loss was similar to injectable Wegovy when tablets were taken as directed.

How this projection works

We take the average loss reported in OASIS 4 (307 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 64. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy pill at 290 lb?

If you matched the OASIS 4 average at 25 mg (13.6%), you'd lose about 39 lb over 64 weeks. Many people lose more or less.

How fast does Wegovy pill weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 28 lb at 25 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error