Skip to content

Projection · OASIS 4

Wegovy pill weight loss from 250 lb

If you match the trial average at 25 mg, you'd be about 216 lb by week 64.

Clinician review pending Updated
Avg loss by week 64
−34lb
25 mg, 13.6%
Weight at week 64
216lb
if you match the average
Placebo group
−6lb
2.2%, same trial
Trial length
64weeks
OASIS 4
Show the math
Loss = 250 lb × 13.6% = 34 lb
Projected weight from 250 lb
2132232332432530112132435364weeks

Wegovy pill 25 mgPlacebo

Week by week

WeekWegovy pill 25 mg
Week 4−6 lb · 244
Week 8−11 lb · 239
Week 12−15 lb · 235
Week 16−19 lb · 231
Week 24−24 lb · 226
Week 36−29 lb · 221
Week 52−33 lb · 217
Week 64−34 lb · 216

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 250 lb

LossPoundsNew weight
5%12 lb238 lb
10%25 lb225 lb
15%38 lb212 lb
20%50 lb200 lb
25%62 lb188 lb

Weight loss was similar to injectable Wegovy when tablets were taken as directed.

How this projection works

We take the average loss reported in OASIS 4 (307 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 64. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy pill at 250 lb?

If you matched the OASIS 4 average at 25 mg (13.6%), you'd lose about 34 lb over 64 weeks. Many people lose more or less.

How fast does Wegovy pill weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 24 lb at 25 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error