Skip to content

Dose step 6 of 6

Zepbound 15 mg

This is the highest dose on the label. Once here, most people stay on it unless side effects or their prescriber's plan say otherwise.

Clinician review pending Updated
Step
6 of 6
on the label
Timing
wk 21 onward
fastest schedule
Length
ongoing
Next step
none
highest dose

Where 15 mg sits on the ladder

What the label says

Zepbound 15 mg: Highest dose on the label.

This is the highest dose on the label. Once here, most people stay on it unless side effects or their prescriber's plan say otherwise.

Most common side effects on Zepbound

Side effectZepboundPlacebo
Nausea25% to 29%9%
Diarrhea19% to 23%7%
Constipation11% to 17%6%

Rates across all label doses, not this step alone. Pooled placebo-controlled weight-management trials in the Zepbound label (5 mg, 10 mg and 15 mg).

Is 15 mg a maintenance dose?

Yes. The label lists maintenance as 5 mg, 10 mg or 15 mg once weekly (10 mg or 15 mg for sleep apnea).

Common questions

How long do you stay on Zepbound 15 mg?

There's no set end; it's the highest label dose.

What comes after Zepbound 15 mg?

Nothing. It's the highest dose on the label.

Can you stay on Zepbound 15 mg longer?

Yes. Holding a dose longer is common when side effects need time to settle. Your prescriber decides.

Sources

  1. Zepbound prescribing information (FDA label on DailyMed)
  2. SURMOUNT-1 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error