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Projection · OASIS 4

Wegovy pill weight loss from 400 lb

If you match the trial average at 25 mg, you'd be about 346 lb by week 64.

Clinician review pending Updated
Avg loss by week 64
−54lb
25 mg, 13.6%
Weight at week 64
346lb
if you match the average
Placebo group
−9lb
2.2%, same trial
Trial length
64weeks
OASIS 4
Show the math
Loss = 400 lb × 13.6% = 54 lb
Projected weight from 400 lb
3413573733894040112132435364weeks

Wegovy pill 25 mgPlacebo

Week by week

WeekWegovy pill 25 mg
Week 4−10 lb · 390
Week 8−18 lb · 382
Week 12−25 lb · 375
Week 16−30 lb · 370
Week 24−39 lb · 361
Week 36−47 lb · 353
Week 52−52 lb · 348
Week 64−54 lb · 346

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 400 lb

LossPoundsNew weight
5%20 lb380 lb
10%40 lb360 lb
15%60 lb340 lb
20%80 lb320 lb
25%100 lb300 lb

Weight loss was similar to injectable Wegovy when tablets were taken as directed.

How this projection works

We take the average loss reported in OASIS 4 (307 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 64. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy pill at 400 lb?

If you matched the OASIS 4 average at 25 mg (13.6%), you'd lose about 54 lb over 64 weeks. Many people lose more or less.

How fast does Wegovy pill weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 39 lb at 25 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error