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Projection · OASIS 4

Wegovy pill weight loss from 380 lb

If you match the trial average at 25 mg, you'd be about 328 lb by week 64.

Clinician review pending Updated
Avg loss by week 64
−52lb
25 mg, 13.6%
Weight at week 64
328lb
if you match the average
Placebo group
−8lb
2.2%, same trial
Trial length
64weeks
OASIS 4
Show the math
Loss = 380 lb × 13.6% = 52 lb
Projected weight from 380 lb
3243393543693840112132435364weeks

Wegovy pill 25 mgPlacebo

Week by week

WeekWegovy pill 25 mg
Week 4−9 lb · 371
Week 8−17 lb · 363
Week 12−23 lb · 357
Week 16−29 lb · 351
Week 24−37 lb · 343
Week 36−44 lb · 336
Week 52−50 lb · 330
Week 64−52 lb · 328

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 380 lb

LossPoundsNew weight
5%19 lb361 lb
10%38 lb342 lb
15%57 lb323 lb
20%76 lb304 lb
25%95 lb285 lb

Weight loss was similar to injectable Wegovy when tablets were taken as directed.

How this projection works

We take the average loss reported in OASIS 4 (307 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 64. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy pill at 380 lb?

If you matched the OASIS 4 average at 25 mg (13.6%), you'd lose about 52 lb over 64 weeks. Many people lose more or less.

How fast does Wegovy pill weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 37 lb at 25 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error