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Projection · STEP 1

Wegovy weight loss from 380 lb

If you match the trial average at 2.4 mg, you'd be about 323 lb by week 68.

Clinician review pending Updated
Avg loss by week 68
−57lb
2.4 mg, 14.9%
Weight at week 68
323lb
if you match the average
Placebo group
−9lb
2.4%, same trial
Trial length
68weeks
STEP 1
Show the math
Loss = 380 lb × 14.9% = 57 lb
Projected weight from 380 lb
3193353523683850112334455768weeks

Wegovy 2.4 mgPlacebo

Week by week

WeekWegovy 2.4 mg
Week 4−10 lb · 370
Week 8−18 lb · 362
Week 12−24 lb · 356
Week 16−30 lb · 350
Week 24−39 lb · 341
Week 36−47 lb · 333
Week 52−54 lb · 326
Week 68−57 lb · 323

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 380 lb

LossPoundsNew weight
5%19 lb361 lb
10%38 lb342 lb
15%57 lb323 lb
20%76 lb304 lb
25%95 lb285 lb

86% lost at least 5%, 69% lost at least 10%, about half lost at least 15% and about a third lost at least 20%.

How this projection works

We take the average loss reported in STEP 1 (1,961 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 68. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy at 380 lb?

If you matched the STEP 1 average at 2.4 mg (14.9%), you'd lose about 57 lb over 68 weeks. Many people lose more or less.

How fast does Wegovy weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 39 lb at 2.4 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy prescribing information (FDA label on DailyMed)
  2. STEP 1 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error