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Side effect · Trulicity

Decreased appetite on Trulicity

Losing your appetite is the point of a GLP-1, until it drops so low that you stop getting enough protein and fluids.

Clinician review pending Updated
On Trulicity
5% to 9%
label rate
On placebo
2%
same trials
Extra vs placebo
up to 7points
attributable to the drug, roughly

Placebo-controlled trials in the Trulicity label (0.75 mg and 1.5 mg).

Decreased appetite across GLP-1 medicines

Mounjaroplacebo 1%
11.0%
Saxendaplacebo 3%
10.0%
Rybelsusplacebo 2%
9.0%
Trulicityplacebo 2%
9.0%
Highest rate across label doses. Different trials and populations, so compare with care.

Why it happens

GLP-1 medicines act on appetite centers in the brain, making you feel full sooner and think about food less. Slower stomach emptying keeps you full longer after each meal.

For many people this quiets constant food thoughts. For some, appetite drops so far that meals feel like a chore.

When it starts and fades

Appetite changes often start within the first days and can deepen after each dose increase.

Many people find appetite settles into a steadier pattern on a maintenance dose, though it varies widely from person to person.

What helps

  • Eat protein first at every meal so it does not get crowded out.
  • Set meal times instead of waiting to feel hungry.
  • Use nutrient-dense foods like Greek yogurt, eggs, fish, beans and protein shakes.
  • Drink fluids between meals instead of with them if fullness is a problem.
  • Track intake for a few days to see whether you are eating far below your needs.
  • Keep strength training to help hold on to muscle.

Other Trulicity side effects

Nausea12% to 21%Diarrhea9% to 13%Vomiting6% to 13%Stomach pain7% to 9%Heartburn and indigestion4% to 6%Fatigue4% to 6%

Common questions

How common is decreased appetite on Trulicity?

In the trials behind the label, 5% to 9% of people on Trulicity reported it, vs 2% on placebo.

Is it bad if I am not hungry on Wegovy?

Lower appetite is expected. The concern is when intake falls so low that protein, fluids and nutrients run short.

How much should I eat on a GLP-1?

It depends on your size, activity and goals. Sunny Weigh's TDEE on a GLP-1 and protein-floor tools give personal starting points to discuss with your care team.

Will my appetite come back if I stop?

Trials found that appetite and weight tended to return for many people after stopping treatment.

Sources

  1. Trulicity prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error