Skip to content

Trulicity · Dosage

Trulicity dosage

The label titration for Trulicity, step by step: increase after at least 4 weeks on the current dose.

Clinician review pending Updated
Start
0.75 mg
4 weeks
Steps
4
on the label
Maintenance
0.75 mg to 4.5 mg once weekly
Max
4.5 mg once weekly

Dosage chart

DoseFastest label timingLabel note
0.75 mgWeeks 1 to 4Starting dose.
1.5 mgWeeks 5 to 8Can be increased after at least 4 weeks on 0.75 mg.
3 mgWeeks 9 to 12If more control is needed after at least 4 weeks on 1.5 mg.
4.5 mgWeek 13 onwardIf more control is needed after at least 4 weeks on 3 mg. Highest dose.

The fastest timing assumes every increase happens as soon as the label allows. Prescribers often hold a dose longer; that's common and on-label.

Changing your dose day

You can change the weekly day as long as the last dose was at least 3 days earlier.

Explainer · 0:22

START LOW 2.5 mg weeks 1 to 4 Not a maintenance dose it's there to let your stomach adjust STEP UP SLOWLY 2.557.51012.515 mg each step: 4+ weeks SIDE EFFECTS FOLLOW THE STEPS +2.5 mg+2.5 mg+2.5 mg+2.5 mg flare, then settle how often nausea is reported IT'S OK TO HOLD 7.5 mg · held on-label, common 0:22 · voiced · captions on
GLP-1 doses start low. Zepbound starts at 2.5 mg, a starter dose that gives your gut time to adjust.
0:00 / 0:22
Why GLP-1 doses go up slowly
Read the transcript
  1. GLP-1 doses start low. Zepbound starts at 2.5 mg, a starter dose that gives your gut time to adjust.
  2. After at least 4 weeks, your prescriber may step it up by 2.5 mg, up to a maintenance dose of 5, 10 or 15 mg.
  3. Stomach side effects like nausea often flare for a few days after each increase, then settle on the same dose.
  4. Staying on a dose longer is common and allowed by the label. Never increase faster than your prescription says.

Common questions

What dose does Trulicity start at?

0.75 mg, 4 weeks. It's a starter dose; the label doesn't use it as a maintenance dose.

How fast does the Trulicity dose go up?

Increase after at least 4 weeks on the current dose.

What is the maximum Trulicity dose?

4.5 mg once weekly.

Can I stay on a lower dose of Trulicity?

Yes, if your prescriber agrees. The label allows maintenance at 0.75 mg to 4.5 mg once weekly.

Sources

  1. Trulicity prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error