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Dose step 5 of 6

Mounjaro 12.5 mg

You've just stepped up from 10 mg. Nausea and other stomach effects often flare for a few days after an increase, then settle on the same dose.

Clinician review pending Updated
Step
5 of 6
on the label
Timing
wk 17 to 20
fastest schedule
Length
4 weeks
minimum
Next step
15 mg
if prescribed

Where 12.5 mg sits on the ladder

What the label says

Mounjaro 12.5 mg: Maintenance option.

You've just stepped up from 10 mg. Nausea and other stomach effects often flare for a few days after an increase, then settle on the same dose.

Most common side effects on Mounjaro

Side effectMounjaroPlacebo
Nausea12% to 18%4%
Diarrhea12% to 17%9%
Decreased appetite5% to 11%1%

Rates across all label doses, not this step alone. Pooled placebo-controlled type 2 diabetes trials in the Mounjaro label (5 mg, 10 mg and 15 mg).

Is 12.5 mg a maintenance dose?

No. It's a step between maintenance doses on the label. Your prescriber may still keep you here.

Common questions

How long do you stay on Mounjaro 12.5 mg?

At least 4 weeks on the label before any increase. Many people stay longer.

What comes after Mounjaro 12.5 mg?

The next label step is 15 mg, if your prescriber increases it.

Can you stay on Mounjaro 12.5 mg longer?

Yes. Holding a dose longer is common when side effects need time to settle. Your prescriber decides.

Sources

  1. Mounjaro prescribing information (FDA label on DailyMed)
  2. SURPASS-2 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error