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Projection · STEP 1

Wegovy weight loss from 350 lb

If you match the trial average at 2.4 mg, you'd be about 298 lb by week 68.

Clinician review pending Updated
Avg loss by week 68
−52lb
2.4 mg, 14.9%
Weight at week 68
298lb
if you match the average
Placebo group
−8lb
2.4%, same trial
Trial length
68weeks
STEP 1
Show the math
Loss = 350 lb × 14.9% = 52 lb
Projected weight from 350 lb
2943093243393540112334455768weeks

Wegovy 2.4 mgPlacebo

Week by week

WeekWegovy 2.4 mg
Week 4−9 lb · 341
Week 8−16 lb · 334
Week 12−23 lb · 327
Week 16−28 lb · 322
Week 24−36 lb · 314
Week 36−44 lb · 306
Week 52−49 lb · 301
Week 68−52 lb · 298

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 350 lb

LossPoundsNew weight
5%18 lb332 lb
10%35 lb315 lb
15%52 lb298 lb
20%70 lb280 lb
25%88 lb262 lb

86% lost at least 5%, 69% lost at least 10%, about half lost at least 15% and about a third lost at least 20%.

How this projection works

We take the average loss reported in STEP 1 (1,961 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 68. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy at 350 lb?

If you matched the STEP 1 average at 2.4 mg (14.9%), you'd lose about 52 lb over 68 weeks. Many people lose more or less.

How fast does Wegovy weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 36 lb at 2.4 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy prescribing information (FDA label on DailyMed)
  2. STEP 1 trial publication

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error