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Projection · OASIS 4

Wegovy pill weight loss from 350 lb

If you match the trial average at 25 mg, you'd be about 302 lb by week 64.

Clinician review pending Updated
Avg loss by week 64
−48lb
25 mg, 13.6%
Weight at week 64
302lb
if you match the average
Placebo group
−8lb
2.2%, same trial
Trial length
64weeks
OASIS 4
Show the math
Loss = 350 lb × 13.6% = 48 lb
Projected weight from 350 lb
2993123263403540112132435364weeks

Wegovy pill 25 mgPlacebo

Week by week

WeekWegovy pill 25 mg
Week 4−9 lb · 341
Week 8−16 lb · 334
Week 12−22 lb · 328
Week 16−26 lb · 324
Week 24−34 lb · 316
Week 36−41 lb · 309
Week 52−46 lb · 304
Week 64−48 lb · 302

Pounds lost · weight. A curve shaped to the trial endpoint, not trial data for each week.

What each milestone means at 350 lb

LossPoundsNew weight
5%18 lb332 lb
10%35 lb315 lb
15%52 lb298 lb
20%70 lb280 lb
25%88 lb262 lb

Weight loss was similar to injectable Wegovy when tablets were taken as directed.

How this projection works

We take the average loss reported in OASIS 4 (307 adults with obesity or overweight, without diabetes) and fit a smooth curve that reaches it at week 64. Real progress is lumpier: early weeks include water, increases follow the dose steps, and individual results range widely around the average. Diet and activity changes were part of the trial for everyone, including placebo.

Other start weights

Common questions

How much weight can you lose on Wegovy pill at 350 lb?

If you matched the OASIS 4 average at 25 mg (13.6%), you'd lose about 48 lb over 64 weeks. Many people lose more or less.

How fast does Wegovy pill weight loss happen?

Loss is fastest in the first months and slows as you near the plateau. By week 24, the curve here shows about 34 lb at 25 mg.

Is this a guarantee?

No. It's an average from a trial, applied to your start weight. Your prescriber and your own weigh-ins are the real guide.

Sources

  1. Wegovy pill prescribing information (FDA label on DailyMed)

Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error