What it means
The National Library of Medicine describes lipedema as a disorder of fat tissue with symmetric enlargement of both legs. The feet are usually spared, which can create a cuff of tissue at the ankles. The affected areas are often tender and bruise easily.
It often starts or worsens around puberty, pregnancy or menopause, which points to a hormonal link, and it tends to run in families. The cause is not known and there is no lab test, so diagnosis is based on a clinical exam.
Lipedema is often mistaken for obesity or lymphedema. A key clue is that the affected fat responds poorly to diet and exercise, even when weight elsewhere changes. Over time it can lead to swelling from secondary lymphedema.
Care may include compression, manual lymph drainage, movement and, for some, surgery. Overall weight management still helps general health and mobility.
Why it matters
People with lipedema may see less change in their legs on a GLP-1 than elsewhere, which is worth knowing upfront.
Related terms
Sources
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