What it means
Also called the treatment-policy estimand, it reflects real-world messiness: some people stop because of side effects, cost or other reasons, and their results still count.
Because of that, this number is usually a little lower than the efficacy estimand. FDA labels often lead with this more conservative figure.
If you are trying to guess what might happen in everyday life, where some people pause or stop treatment, this estimand is a sensible reference.
Trials use statistical methods to fill in missing data for people who left early. The exact method can nudge the result, which is another reason to read the trial's own report. It is often the figure quoted first in FDA labels and press releases, so it is worth knowing what it includes.
Why it matters
It gives the more cautious view of expected weight loss used in Sunny Weigh's lower projection range.