Mounjaro
tirzepatide · Eli Lilly
Trulicity
dulaglutide · Eli Lilly
Side by side
| Mounjaro | Trulicity | |
|---|---|---|
| Active ingredient | tirzepatide | dulaglutide |
| Maker | Eli Lilly | Eli Lilly |
| Class | GIP and GLP-1 receptor agonist | GLP-1 receptor agonist |
| Approved for | Type 2 diabetes | Type 2 diabetes |
| How you take it | once weekly injection | once weekly injection |
| Starting dose | 2.5 mg | 0.75 mg |
| Highest dose | 15 mg | 4.5 mg |
| Main trial result | A1C fell 2.0 to 2.3 points and weight fell about 17 to 25 lb across doses; semaglutide 1 mg lowered A1C 1.9 points and weight about 13 lb | A1C fell about 0.8 to 1.6 points depending on dose and background therapy, with modest weight loss |
| Nausea (label) | 12% to 18% vs 4% placebo | 12% to 21% vs 5% placebo |
| Missed-dose window | 4 days (96 hours) | until 3 days (72 hours) before the next dose |
| Out of the fridge | Up to 21 days at or below 86°F (30°C) | Up to 14 days at or below 86°F (30°C) |
| List price | $1,080/mo | $986/mo |
| Lowest self-pay | not offered | not offered |
Prices compiled mid-2026 from manufacturer announcements; re-checked monthly.
Key differences
- Different molecules. Mounjaro is tirzepatide (GIP and GLP-1 receptor agonist); Trulicity is dulaglutide (GLP-1 receptor agonist).
Which one fits you
That's a decision for you and your prescriber. The factors that usually decide it:
- Your diagnosis, which decides the approved option and often the coverage
- Whether your plan covers one and not the other
- A shot or a pill, weekly or daily
- How you tolerate side effects
- Cost if you pay yourself: see the cost index
Common questions
Is Mounjaro the same as Trulicity?
No. They contain different medicines: tirzepatide and dulaglutide.
Which works better for weight loss, Mounjaro or Trulicity?
Their main trials were separate, so a direct ranking isn't possible from that data. Your prescriber can weigh your history.
Can I switch from Mounjaro to Trulicity?
Only with your prescriber. Switching usually means a new starting dose, not a direct swap.
Which is cheaper, Mounjaro or Trulicity?
List prices are $1,080/mo and $986/mo a month; lowest self-pay options we track are not offered and not offered. Coverage usually matters more.
Sources
Clinician review pending. Drafted from primary sources and waiting for sign-off by a licensed clinician (MD, DO or PharmD) before launch. Every number is checked against its source. Drug facts are re-checked quarterly, prices monthly and whenever a label changes. How we review · Report an error