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One year after stopping semaglutide in the STEP 1 extension, people had regained about two-thirds of the weight they had lost.
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Obesity is treated as a chronic condition, and the FDA labels describe Zepbound and Wegovy for chronic weight management.
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Trial Drug What happened after stopping STEP 1 extension Semaglutide 2.4 mg People had lost about 17% of body weight.
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When the drug leaves your system, appetite signals return to their old levels.
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Some people stop because of cost, side effects, pregnancy plans or coverage changes.
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Coverage gaps, shortages and surgery mean many people pause and restart.
What the STEP 1 extension and SURMOUNT-4 trials found about weight regain after stopping semaglutide or tirzepatide, and how to plan it with your doctor.
Tap below for the full page. Not medical advice; talk to your clinician about your care.