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MC4R is a receptor in the brain's hypothalamus that helps control hunger and energy use, and changes in its pathway can cause severe early obesity.
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When fat stores are adequate, the hormone leptin triggers nerve cells to make a signal that activates MC4R.
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MC4R explains why a small group of people need a very different treatment approach than standard weight-loss medicines.
MC4R is a receptor in the brain's hypothalamus that helps control hunger and energy use, and changes in its pathway can cause severe early obesity.
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