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Side effect

Injection-site reactions on GLP-1 medicines: what helps

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Injection-site reactions on GLP-1s

Redness or itching where you inject is usually mild and short-lived, and rotating sites each week is the easiest way to cut it down.

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Why it happens

Any shot under the skin can irritate the tissue, cause a small bruise or trigger a mild local immune response to the medicine.

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When it shows up

Reactions usually appear within hours to a day after a shot and fade over a few days.

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What helps

Rotate sites each week among the abdomen, thigh and upper arm as your label allows.

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What helps

Inject at least a couple of inches away from the last spot.

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Call your doctor if

Swelling of the face, lips, tongue or throat, trouble breathing or a fast heartbeat: call 911, as this may be a serious allergic reaction.

Want the full picture?

Redness, itching, swelling or bruising at the injection spot is listed in GLP-1 label tables. Most reactions fade within a few days.

Tap below for the full page. Not medical advice; talk to your clinician about your care.

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