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Side effect

Fatigue on GLP-1 medicines: what helps

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Photo: Ellie Ellien / Unsplash

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Fatigue on GLP-1s

If you are eating hundreds of calories less than before, feeling tired is often your energy budget talking, not just the drug.

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Why it happens

GLP-1 medicines can cut appetite sharply.

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When it shows up

Fatigue tends to be most noticeable in the early weeks and after dose increases, when appetite drops the most.

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What helps

Hit a daily protein floor, even on low-appetite days.

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What helps

Eat at regular times rather than going most of the day without food.

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Call your doctor if

Extreme tiredness with dizziness, fainting or a racing heart.

Want the full picture?

Fatigue is listed in GLP-1 label tables and is often tied to a big drop in food and fluid intake. Protein, steady meals and sleep help many people.

Tap below for the full page. Not medical advice; talk to your clinician about your care.

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